Selected Publications

Note: *Authors Contributed Equally; # Co-correspondence; lab started in 2005

2025

  • Chakraborty S, Cheng BY, Edwards DL, Gonzalez JC, Chiu DK, Zheng H, Scallan C, Guo X, Tan GS, Coffey GP, Conley PB, Hume PS, Janssen WJ, Byers DE, Mudd PA, Taubenberger J, Memoli M, Davis MM, Chua KF, Diamond MS, Andreakos E, Khatri P, Wang TT. Sialylated IgG induces the transcription factor REST in alveolar macrophages to protect against lung inflammation and severe influenza disease. Immunity. 2025 Jan 14;58(1):182-196.e10.

2023

  • Mealey-Farr R, Jeong J, Park J, Liu S, Hausmann S, Francis JW, Angulo-Ibanez M, Cho J, Chua KF, Mazur PK, Gozani O. (2023) Antibody toolkit to investigate eEF1A methylation dynamics in mRNA translation elongation. The Journal of biological chemistry: 104747. PMID: 37094697; PMCID: PMC10220242.

2021

  • Zheng W, Tasselli L, Li TM, Chua KF. Mammalian SIRT6 Represses Invasive Cancer Cell Phenotypes through ATP Citrate Lyase (ACLY)-Dependent Histone Acetylation. Genes. 2021 Sep 21;12(9):1460.

  • Yuan G, Flores NM, Hausmann S, Lofgren SM, Kharchenko V, Angulo-Ibanez M, Sengupta D, Lu X, Czaban I, Azhibek D, Vicent S, Fischle W, Jaremko M, Fang B, Wistuba II, Chua KF, Roth JA, Minna JD, Shao NY, Jaremko L, Mazur PK and Gozani O (2021). Elevated NSD3 Histone Methylation Activity Drives Squamous Cell Lung Cancer. Nature, 590, 504–508.

  • Slaughter MJ, Shanle EK, Khan A, Chua KF, Hong T, Boxer LD, Allis CD, Josefowicz SZ, Garcia BA, Rothbart SB, Strahl BD, Davis IJ. HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies. Cell Rep. 2021 Jan 19;34(3):108638.

2020

  • Li TM, Ren J, Husmann D, Coan JP, Gozani O#, Chua KF#. Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation. Sci Rep. 2020 Oct 15;10(1):17425. PMID: 33060621

2019

  • You W, Zheng W, Weiss S, Chua KF, Steegborn C. Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives. Scientific Reports. 2019 Dec 16;9(1):19176.

  • Li TM, Coan JP, Krajewski K, Zhang L, Elias JE, Strahl BD, Gozani O, and Chua KF (2019). Binding to medium and long chain fatty acyls is a common property of HEAT and ARM repeat modules. Scientific Reports. 2019 Oct 2;9(1):14226. PMID 315784817

  • Wang WW, Angulo-Ibanez M, Lyu J, Kurra Y, Tong Z, Wu B, Zhang L, Sharma V, Zhou J, Lin H, Gao YQ, Li W, Chua KF, Liu WR. A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7. J Am Chem Soc. 2019 Feb 13;141(6):2462-2473.

2018

  • Paredes S, Angulo-Ibanez M, Tasselli L, Carlson SM, Zheng W, Li TM, Chua KF. The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability. J Biol Chem. 2018 Jul 13;293(28):11242-11250.

  • M Ibanez, KF Chua. Chromatin and Nuclear Signaling: SIRT7 Function in the Nucleolus and Beyond. 2018. Introductory Review on Sirtuins in Biology, Aging, and Disease. [PDF]

2017

  • You W, Rotili D, Li TM, Kambach C, Meleshin M, Schutkowski M, Chua KF, Mai A, Steegborn C. Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules. Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1007-1011.

  • L Tasselli, W Zheng, and KF Chua. SIRT6: Novel Mechanisms and Links to Aging and Disease. 2017. Trends Endocrinol Metab. 2017 Mar;28(3):168-185. [PDF]

2016

  • Paredes S, Chua KF. SIRT7 clears the way for DNA repair. 2016. EMBO J. 2016 Jul 15;35(14):1483-5. [PDF]

  • Tasselli L, Xi Y, Zheng W, Tennen RI, Odrowaz Z, Simeoni F, Li W, Chua KF. SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence. Nat Struct Mol Biol. 2016 May;23(5):434-40.

  • E Fang, M Scheibye-Knudsen, KF Chua, M Mattson, D Croteau, and V Bohr. Nuclear DNA damage signalling to mitochondria in ageing. 2016. Nat Rev Mol Cell Biol. 2016 May;17(5):308-21. [PDF]

2015

  • Malik S, Villanova L, Tanaka S, Aonuma M, Roy N, Berber E, Pollack JR, Michishita-Kioi E, Chua KF. SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors. Sci Rep. 2015 Apr 29;5:9841.

  • L Tasselli and KF Chua. Methylation gets into rhythm with NAD+-SIRT1. 2015. Nat Struct Mol Biol. 2015 Apr;22(4):275-7. [PDF]

2014

  • S Paredes, L Villanova and KF Chua. Molecular Pathways: Emerging Roles of Mammalian Sirtuin SIRT7 in Cancer. 2014. Clin Cancer Res. 2014 Apr 1;20(7):1741-6. [PDF]

2013

  • Shin J, He M, Liu Y, Paredes S, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, Kapahi P, Krauss R, Mostoslavsky R, Yancopoulos GD, Alt FW, Chua KF, Chen D. SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep. 2013 Nov 14;5(3):654-665.

  • Simeoni F, Tasselli L, Tanaka S, Villanova L, Hayashi M, Kubota K, Isono F, Garcia BA, Michishita-Kioi E, Chua KF. Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling. Sci Rep. 2013 Oct 30;3:3085.

  • Sharma A, Diecke S, Zhang WY, Lan F, He C, Mordwinkin NM, Chua KF, Wu JC. The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells. J Biol Chem. 2013 Jun 21;288(25):18439-47.

  • Moore KE, Carlson SM, Camp ND, Cheung P, James RG, Chua KF, Wolf-Yadlin A, Gozani O. A General Molecular Affinity Strategy for Global Detection and Proteomic Analysis of Lysine Methylation. Mol Cell. 2013 May 9;50(3):444-56. PMID: 23583077

2012

  • Tasselli L, Chua KF. Cancer: Metabolism in 'the driver's seat. Nature. 2012 Dec 20;492(7429):362-3. [PDF]

  • Barber MF*, Michishita-Kioi E*, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, Tennen RI, Paredes S, Young NL, Chen K, Struhl K, Garcia BA, Gozani O, Li W, Chua KF. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature. 2012 Jul 5;487(7405):114-8. PMID: 22722849

  • Tennen RI, Michishita-Kioi E, Chua KF. Finding a target for resveratrol. Cell. 2012 Feb 3;148(3):387-9.

2011

  • Tennen RI, Bua DJ, Wright WE, Chua KF. SIRT6 is required for maintenance of telomere position effect in human cells. Nat Commun. 2011 Aug 16;2:433.

  • Dan Levy, Alex J. Kuo, Yanqi Chang, Uwe Schaefer, Christopher Kitson, Peggie Cheung, Alexsandra Espejo, Barry M. Zee, Chih Long Liu, Stephanie Tangsombatvisit, Ruth I. Tennen, Andrew Y. Kuo, Song Tanjing, Regina Cheung, Katrin F. Chua, Paul J. Utz, Xiaobing Shi, Rab K. Prinjha, Kevin Lee, Benjamin A. Garcia, Mark T. Bedford, Alexander Tarakhovsky, Xiaodong Cheng and Or Gozani. Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat Immunol. 2011 Jan;12(1):29-36. PMID: 21131967

  • Tennen RI, Chua KF. Chromatin regulation and genome maintenance by mammalian SIRT6. Trends Biochem Sci. 2011 Jan;36(1):39-46.

2010

  • Tennen RI, Berber E, Chua KF. Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization. Mech Ageing Dev. 2010 Mar;131(3):185-92.

2009

  • Michishita E, McCord RA, Boxer LD, Barber MF, Hong T, Gozani O, Chua KF. Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. Cell Cycle. 2009 Aug 15;8(16):2664-6. PMID: 19625767

  • Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KC, Boxer LD, Chang HY, Chua KF. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell. 2009 Jan 9;136(1):62-74.

  • McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, Guan S, Shi X, Gozani O, Burlingame AL, Bohr VA, and Chua KF. SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair. Aging . 2009 Jan 15;1(1):109-21. PMID: 20157594

2008

  • Michishita, E., McCord, R.A., Berber E., Kioi, M., Padilla-Nash, H,, Damian, M., Cheung, P., Kusomoto, R., Kawahara, T.L.A., Barrett, J.C., Chang, H.Y., Bohr, V.A., Ried, T., Gozani, O. and K.F. Chua. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature. 2008 Mar 27;452(7186):492-6. PMID: 18337721

2006

  • Xiaobing Shi, Tao Hong, Kay L. Walter, Mark Ewalt, Eriko Michishita, Tiffany Hung, Dylan Carney, Pedro Peña, Fei Lan, Mohan R. Kaadige, Nicolas Lacoste, Christelle Cayrou Foteini Davrazou, Anjanabha Saha, Bradley R. Cairns, Donald E. Ayer, Tatiana G. Kutateladze, Yang Shi, Jacques Côté, Katrin F. Chua, and Or Gozani. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature. 2006 Jul 6;442(7098):96-9. PMID: 16728974

  • Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 2006 Jan 27;124(2):315-29.

Prior to 2006

  • Berglund JA, Chua K, Abovich N, Reed R, Rosbash M (1997). The splicing factor BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC. Cell 89:781-787.

  • Seghezzi W, Chua K, Shanahan F, Gozani O, Reed R, Lees E (1998). Cyclin E associates with components of the pre-mRNA splicing machinery in mammalian cells. Molecular and Cellular Biology 18:4526-4536.

  • Wang C, Chua K, Seghezzi W, Lees E, Gozani O, and Reed R (1998). Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis. Genes and Development 12:1409-1414.

  • Chua K and Reed R (1999). Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing. Genes and Development 13:841-850.

  • Chua K and Reed R (1999). The RNA splicing factor hSlu7 is required for correct 3’ splice-site choice. Nature 402:207-210.

  • Chua K and Reed R (2001). An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing. Molecular and Cellular Biology 21:1509-1514.

  • Chua KF, Alt FW, and Manis JP (2002). The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks. Journal of Experimental Medicine 195: F37-F41.

  • Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, Fleming JC, Monroe BC, Ciccone DN, Yan C, Vlasakova K, Livingston DM, Ferguson DO, Scully R and Alt FW (2002). Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proceedings of the National Academy of Sciences 99:8173-8178.

  • Shinkura R, Tian M, Smith M, Chua KF and Alt FW (2003). The influence of transcriptional orientation on endogenous switch region function. Nature Immunology 4:435-441.

  • Chaudhuri J, Tian M, Khuong C, Chua KF, Pinaud E and Alt FW (2003). Transcription targeted DNA deamination by the AID antibody diversification enzyme. Nature 422:726-730.

  • Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M, Gleason M, Bronson R, Lee C, Alt FW (2003). Histone H2AX: a dosage dependent suppressor of oncogenic translocations and tumors. Cell 114:359-370.

  • Cheng H-L, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chua KF (2003). Developmental defects and p53 hyperacetylation in SIR2 homolog (SIRT1)-deficient mice. Proceedings of the National Academy of Sciences 100:10794-10799.

  • Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng H-L, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME (2004). Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303:2011-2015.

  • Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S, Kaushal D, Cheng H, Fischer MR, Murphy MM, Appella E, and Alt FW (2005). Mammalian SIRT1 limits replicative lifespan in response to chronic genotoxic stress. Cell Metabolism 2: 67-76.