Stanford Medical School / Department of Medicine
Chromatin and Epigenetic Regulation in Aging and Disease
Our lab investigates fundamental mechanisms of aging, and aging-associated disease processes, combining biochemical, cell and molecular biology, multi-omics, epigenetics, and mouse model approaches. We focus on chromatin regulation and nuclear programming by mammalian SIRT6 and SIRT7 – NAD⁺-dependent lysine deacetylase enzymes that play essential roles in maintaining genome stability and cellular homeostasis.
Our goals include:
Elucidating molecular mechanisms by which SIRT6 and SIRT7 regulate chromatin structure, epigenetic programs, and nuclear signaling pathways, and understanding how disruption of these mechanisms drives aging, cancer, and metabolic dysfunction
Pioneering proteomic technologies to discover novel sirtuin substrates and functional interactions that reveal new connections between chromatin regulation and human disease
Translating mechanistic insights into therapeutic strategies by identifying clinically actionable targets within sirtuin-regulated pathways for treating age-related diseases and cancer
Want to learn more about our work? Check out our active areas of investigation and publications.
Interested in joining the lab or discussing potential projects? We’re recruiting for multiple roles.